About us

VerdAscend Mission

Our goal is to employ computational tools and methods to effectively and efficiently solve customer problems.


Ryan Koehler is the founder and principal at VerdAscend Sciences. Dr. Koehler has worked in industry as a computational chemist supporting drug discovery efforts, and as a bioinformatics scientist developing software and computational tools to facilitate assay design, data mining and data analysis in the context of biotechnology. Work at VerdAscend draws on all of this experience to solve important client problems.

Ryan has a B.S. in Biochemistry from the University of California at Davis and a Ph.D. in Chemistry from UC Santa Cruz. He also teaches biotech-related courses through UC San Deigo extension.

Ryan's professional profile is here: http://www.linkedin.com/in/ryantkoehler

Publications, from Google Scholar

Link here: Ryan T Koehler

... Or, Listed with PubMed links

B.J.Hindson, et al. High-throughput droplet digital PCR system for absolute quantitation of DNA copy number. Anal Chem. 15, 8604-10, 2011.

R.T.Koehler, et al. The uniqueome: a mappability resource for short-tag sequencing. Bioinformatics, 15, 272-4. 2011.

R.T. Koehler, N. Peyret. Effects of DNA Secondary Structure on Oligonucleotide Probe Binding Efficiency. Computational Biology and Chemistry. 29, 393-7, 2005

R.T. Koehler, N. Peyret. Thermodynamic properties of DNA sequences: Characteristic Values for the Human Genome. Bioinformatics. 16, 3333-9, 2005.

F.M. De La Vega, et al. The Linkage Disequilibrium Maps of Three Human
Chromosomes Across Four Populations Reflect Their Demographic History and A Common Underlying Recombination Pattern
. Genome Res. 15, 454-62, 2005.

A.R. Tobler, et al. The SNPlex genotyping system: a flexible and scalable platform for SNP genotyping. J Biomol Tech. 16, 398-406, 2005.

R.T. Koehler, H.O. Villar. Design of Screening Libraries Biased for Pharmaceutical Discovery. J. Comp. Chem. 21, 1145-52, 2000.

H.O. Villar, R.T. Koehler. Comments on the Design of  Chemical Libraries for Screening. Molecular Diversity 5, 13-24, 2000.

R.T. Koehler, H.O. Villar. Statistical Relationships Among Docking Score for Different Protein Binding Sites. J. Computer Aided Molecular. Design. 14, 23-37, 2000.

H.O. Villar, R.T. Koehler. Amino acid preferences of small naturally occurring polypeptides. Biopolymers. 53, 226-32, 2000.

R.T. Koehler, S.L. Dixon, H.O. Villar. LASSOO: A Generalized Directed Diversity Approach to the Design and Enrichment of Chemical Libraries. J. Med. Chem. 42,
4695-4704, 1999.

S.L. Dixon, R.T. Koehler. The Hidden Component of Size in 2D Fragment Descriptors: Side-Effects on Sampling in Bioactive Libraries. J. Med. Chem. 42, 2887-2900, 1999.

R.T. Koehler, H.O. Villar, K.E. Bauer, D.L. Higgins. Ligand-Based Protein Alignment and the Specificity of Glutathione S-Tranferase Inhibitors. Proteins, Structure, Function and Genetics. 28, 202-16, 1997.

R.T. Koehler, W.T. Wipke. Molecular Population Fogs. Presented at the 13’th Annual Meeting of the Molecular Graphics Society, Chicago IL, July 1994.